Overview

The aim of this course is to provide an introduction to continuous chromatography with hands-on practice with capture and polishing processes for biomolecules. These processes lead to improvements in productivity and manufacturing costs and may be even enabling in difficult purification challenges, such as antibody-drug conjugates or biosimilars. Attendees will acquire the basic tools to design, run and evaluate multicolumn processes and to quantify these improvements, serving as basis for an economic evaluation. As the least complex of all multi-column processes, the workshop is focused on twin column chromatography.

• Introduction to continuous chromatography for biomolecules
• Theory of multi-column chromatography
• Design of multi-column chromatography processes
• Hands-on training on twin column equipment capture and polishing applications
• Process performance evaluation and scale-up

This workshop does not cover 4-zone SMB, chiral and small molecule separations.

Massimo Morbidelli, Ph.D., Professor of Chemical Reaction and Separation Technologies in the Department of Chemistry, Politecnico di Milano.

Thomas Müller-Späth, Ph.D., Director of RnD at ChromaCon AG in Zurich.

The course will be held at the University of Applied Sciences and Arts Northwestern Switzerland (FHNW) at the new campus in Muttenz (Basel). The FHNW Muttenz Campus is well served by public transport. International flight connections are available from Basel and Zurich International Airports. Note: As the workshops will take place in a laboratory environment we ask that participants dress appropriately. Safety glasses and lab coats will be provided.

Registration