References
ChromaCon is the technological leader in the field of chromatography for biological molecules, such as proteins and antibodies. Therefore, we regularly engage in R&D projects together with customers. Below, a selection of recent publications from these programs can be found.
Scale-Up of Twin-Column Periodic Counter-Current Chromatography for MAb Purification
Angelo J, Pagano J, Müller-Späth T, Mihlbachler K, Chollangi S, Xu Xu, Ghose S, Li ZJ BioProcess International 2018 .
Experimental design of a twin-column countercurrent gradient purification process
F Steinebach, N Ulmer, L Decker, L Aumann, M Morbidelli, Journal of Chromatography A 2017, 1492, 19-26 .
Design and operation of a continuous integrated monoclonal antibody production process
F. Steinebach, N. Ulmer, M. Wolf, L. Decker, V. Schneider, R. Wälchli, D. Karst, J. Souquet, M. Morbidelli, Biotechnology Progress 2017, 33 (5), 1303–1313.
Comparison of batch and continuous multi-column protein A capture processes by optimal design
D. Baur, M. Angarita, T. Müller-Späth, F. Steinebach, M. Morbidelli, Biotechnology Journal 2016, 11 (7), 920-931.
Optimal model-based design of the twin-column CaptureSMB process improves capacity utilization and productivity in protein A affinity capture
D. Baur, M. Angarita, T. Müller-Späth, M. Morbidelli, Biotechnology Journal 2016, 11 (1), 135-145.
Twin-column CaptureSMB: a novel cyclic process for protein A affinity chromatography
M. Angarita, T. Müller-Späth, D. Baur, R. Lievrouw, G. Lissens, M. Morbidelli, Journal of Chromatography A 2015, 1389, 85-98.
Twin-Column Cation-Exchange Chromatography for the Purification of Biomolecules
T. Müller-Späth, N. Ulmer, L. Aumann, C. Kennedy, M. Bavand, Biopharm International 2015, 28 (4), 32-36. Free access.
Affinity Capture of F (ab’)2 Fragments: Using Twin-Column Countercurrent Chromatography
N. Ulmer, T. Müller-Späth, B. Neunstoecklin, L. Aumann, M. Bavand, M. Morbidelli, BioProcess International 2015, 13 (2), 22-29. Free access.
Increasing Capacity Utilization in Protein A Chromatography
T. Müller-Späth, M. Angarita, D. Baur, R. Lievrouw, G. Lissens, G. Ströhlein, M. Bavand, M. Morbidelli, Biopharm International 2013, 26 (10), 33-38. Free access.
Enabling high purities and yields in therapeutic peptide purification using multicolumn countercurrent solvent gradient purification
T. Müller-Späth, G. Ströhlein, O. Lyngberg, D. Maclean, Chimica Oggi-Chemistry Today 2013, 31 (5), 56-61. Free access.
Purifying Common Light-Chain Bispecific Antibodies: A Twin-Column, Countercurrent Chromatography Platform Process
T. Müller-Späth, N. Ulmer, L. Aumann, G. Ströhlein, M. Bavand, L.J.A. Hendriks, J. de Kruif, M. Throsby, A.B.H. Bakker, BioProcess International 2013, 11 (3), 36-45. Free access.
Productivity Boost for Biopurification: Twin-Column Ultra-High Resolution Chromatography.
T. Müller-Späth, G. Ströhlein, M. Bavand, Genetic Engineering & Biotechnology News, May 15 2013 (Vol. 33, No. 10). Free access.
Multifraction separation in countercurrent chromatography (MCSGP)
M. Krättli, T. Müller-Späth, M. Morbidelli, Biotechnology and Bioengineering 2013, 110 (9), 2436–2444.
Separation of Lanthanides by Continuous Chromatography
M. Krättli, T. Müller-Späth, N. Ulmer, G. Ströhlein and M. Morbidelli, Industrial Engineering & Chemical Research 2013, 52 (26), 8880–8886.
Purification of a synthetic peptide using multi-column chromatography (Contichrom® & MCSGP)
G. Ströhlein, T. Müller-Späth, O. Lyngberg, D. Maclean, Poster presentation at PREP Symposium 2012. Free access.
Two step capture and purification of IgG2 using multicolumn countercurrent solvent gradient purification (MCSGP)
T. Müller-Späth, L. Aumann, G. Ströhlein, H. Kornmann, P. Valax, L. Delegrange, E. Charbaut, G. Baer, A. Lamproye, M. Jöhnck, M. Schulte, M. Morbidelli, Biotechnology and Bioengineering 2010, 107 (6), 974-984.
Increasing the activity of monoclonal antibody therapeutics by continuous chromatography (MCSGP)
T. Müller-Späth, M. Krättli, L. Aumann, G. Ströhlein, M. Morbidelli, Biotechnology and Bioengineering 2010, 107 (4), 652-662.
Peptide Purification using the Multicolumn Countercurrent Solvent Gradient Purification (MCSGP) Process
L. Aumann, G. Stroehlein, B. Schenkel, M. Morbidelli, Biopharm. International 2009, 22(1). Free access.
Chromatographic separation of three monoclonal antibody variants using multicolumn countercurrent solvent gradient purification (MCSGP)
T. Müller-Späth, L. Aumann, L. Melter, G. Ströhlein, M. Morbidelli, Biotechnology and Bioengineering 2008, 100, 1166-1177.
CONTINUOUS PROCESSING: The Multicolumn Countercurrent Solvent Gradient Purification Process
G. Ströhlein, L. Aumann, T. Müller-Späth, A. Tarafder, M. Morbidelli, Biopharm. International, 02/2007. Free access.
Others on Contichrom Systems
Simulation, optimization and implementation of a twin-column MCSGP process for the purification of Liraglutide
J. Gomis Fons, Master thesis, Lund University, Lund, Sweden, 2017 .
The ideal peptide plant
O. Ludemann-Hombourger, Specialty Chemicals Magazine, May 2013, 30-33 . Free access.
Online control of the twin-column countercurrent solvent gradient process for biochromatography
M. Krättli, F. Steinebach, M. Morbidelli, Journal of Chromatography A 2013, 1293, 51-59 .
